'Still Life with Skull' is a study piece depicting fruits and a human skull, arranged on a hanging piece of deep red cloth. Byer was usually known for her metalwork, inspired by her love of steel pan, including renowned pieces such as 'The Cockatrice' and 'The Loving Cup of Hebe'. However, this oil painting is a testament to her passion and expertise in painting, which was also reflected in her work in art restorations throughout the Caribbean.